Tian Lab
@ SYSUCC

2026
^: co-first author;          
*: corresponding author;          
bold: team members
A click-compatible BmTyr platform for biotin-free proximity labeling and subcellular profiling in primary T cells, Xin-nan Zheng, Jing-min Zeng, Han-ying Huang, Chuang Zhao, Suo-sheng Ma, Lin Feng, Hao Zhu, Lin Tian*, Biochemical and Biophysical Research Communications, 822:153918, PMID: 42119177
In vivo Sortase A-mediated LPETG Ligation for Rare Cell Enrichment, Han-ying Huang, Jing-min Zeng, Lin Tian*, Journal of Visualized Experiments, 7:234, PMID: 42611792
2025
Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer, Yuetong Zhang^, Jiaying Chen^, Yong She^, Zhaoyuan Fang^, Yaxin Zhang, Danyun Ruan, Wenjun Guo, Jianping Liao, Weiping Zhou, Jianpei Lao, Weicheng Fang, Xingyan Pan, Wenfei Kang, Zifeng Wang, Yuanzhong Wu, Rong Deng, Lin Tian, Liqin Wang, Huilin Huang, Jian Zheng, Yan Yan, Hezhe Lu, Ruiping Wang, Rona Yaeger, Qi Zhao*, Wenting Liao*, Feng Wang*, Yijun Gao*, Cancer Cell: 44(1):77-93, PMID: 41237766
Kill two birds with one stone: reprogramming tumor microenvironment with Growth Differentiation Factor 11, Han-ying Huang, Lin Tian*, World Journal of Gastroenterology, 32(9):115259, PMID: 41810435, invited by the editor
Vascular-Associated Mononuclear Phagocytes: First-Line Soldiers Ambushing Metastasis, Han-ying Huang^, Xin-nan Zheng^, Lin Tian*, Bioessays, 47(3):e202400261, PMID: 39988942, invited by the editor
Vascular Normalization Augments the Anti-tumor Efficacy of Combined HDAC Inhibitor with Immunotherapy in Solid Tumors, Min Wang^, Yanxing Chen^, Lin Tian^, Chenyi Wu^, Jiaying Chen^, Jiajia Hu^, Runjie Huang, Yingnan Wang, Jinling Zhang, Xiao-Jie Ouyang, Liqin Wang, Ying Jin, Qi Zhao, Feng Wang*, Rui-Hua Xu*, Cancer Discovery: 15(9):1883-1904, PMID: 40452600
Cytidine triphosphate synthase 1-mediated metabolic reprogramming promotes proliferation and drug resistance in multiple myelomas, Han-ying Huang^, Yan-zhou Chen^, Yang Li^, Xin-nan Zheng, Ling-ling Shu, Lin Tian, Huan-xin Lin*, Yang Liang*, Heliyon: 10(13):e33001, PMID: 39050461
Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain, Siting Gan, Danilo G Macalinao, Sayyed Hamed Shahoei, Lin Tian, Xin Jin, Harihar Basnet, Catherine Bibby, James T Muller, Pranita Atri, Evan Seffar, Walid Chatila, Ali Karacay, Pharto Chanda, Anna-Katerina Hadjantonakis, Nikolaus Schultz, Edi Brogi, Tejus A Bale, Nelson S Moss, Rajmohan Murali, Dana Pe'er, Joan Massagué*, Cancer Cell: 42(10):1693, PMID: 39270646
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial, Feng Wang*^, Ying Jin^, Min Wang^, Hui-Yan Luo^, Wei-Jia Fang^, Ying-Nan Wang, Yan-Xing Chen, Run-Jie Huang, Wen-Long Guan, Ji-Bin Li, Yu-Hong Li, Feng-Hua Wang, Xiao-Hua Hu, Yan-Qiao Zhang, Miao-Zhen Qiu, Lu-Lu Liu, Zi-Xian Wang, Chao Ren, De-Shen Wang, Dong-Sheng Zhang, Zhi-Qiang Wang, Wen-Ting Liao, Lin Tian, Qi Zhao, Rui-Hua Xu*, Nature Medicine: 30(4):1035-1043, PMID: 38438735
2023
An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma, Yan-Xing Chen^, Zi-Xian Wang^, Ying Jin^, Qi Zhao^, Ze-Xian Liu, Zhi-Xiang Zuo, Huai-Qiang Ju, Chengxu Cui, Jun Yao, Yanqiao Zhang, Mengxia Li, Jifeng Feng, Lin Tian, Xiao-Jun Xia, Hui Feng, Sheng Yao, Feng-Hua Wang, Yu-Hong Li, Feng Wang*, Rui-Hua Xu*, Cancer Cell: 8;41(5):919-932, PMID: 37059106
2021
Hormonal modulation of ESR1 mutant metastasis, Guowei Gu, Lin Tian, Sarah K Herzog, Yassine Rechoum, Luca Gelsomino, Meng Gao, Lili Du, Jin-Ah Kim, Derek Dustin, Hin Ching Lo, Amanda R Beyer, David G Edwards, Thomas Gonzalez, Anna Tsimelzon, Helen J Huang, Natalie M Fernandez, Sandra L Grimm, Susan G Hilsenbeck, Dan Liu, Jun Xu, Alyssa Alaniz, Shunqiang Li, Gordon B Mills, Filip Janku, Ralf Kittler, Xiang H-F Zhang, Cristian Coarfa, Charles E Foulds, W Fraser Symmans, Sebastiano Andò, Suzanne A W Fuqua*, Oncogene: 40(5):997-1011, PMID: 33323970
CD8+ T cells inhibit metastasis and CXCL4 regulates its function, Robiya Joseph^, Rama Soundararajan^, Suhas Vasaikar^, Fei Yang, Kendra L Allton, Lin Tian, Petra den Hollander, Sevinj Isgandarova, Monika Haemmerle, Barbara Mino, Tieling Zhou, Crystal Shin, Melisa Martinez-Paniagua, Aysegul A Sahin, Jaime Rodriguez-Canales, Juri Gelovani, Jeffrey T Chang, Ghanashyam Acharya, Anil K Sood, Ignacio I Wistuba, Don L Gibbons, Luisa M Solis, Michelle C Barton, Navin Varadarajan, Jeffrey M Rosen, Xiang H Zhang, Sendurai A Mani*, British Journal of Cancer.: 125(2):176-189, PMID: 33795809
Previous Publication
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming, Lin Tian, Amit Goldstein, Hai Wang, Hin Ching Lo, Ik Sun Kim, Thomas Welte, Kuanwei Sheng, Lacey E Dobrolecki, Xiaomei Zhang, Nagireddy Putluri, Thuy L Phung, Sendurai A Mani, Fabio Stossi, Arun Sreekumar, Michael A Mancini, William K Decker, Chenghang Zong, Michael T Lewis, Xiang H-F Zhang*, Nature: 544(7649):250-254, PMID: 28371798